Wonderfully Made

Beta-cell Burnout

Three Angels Broadcasting Network

Program transcript

Participants: N. David Emerson

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Series Code: WM

Program Code: WM000428


00:01 The following program presents principles designed
00:03 to promote good health and is not intended to take
00:05 the place of personalized professional care.
00:08 The opinions and ideas expressed are those of the speaker.
00:12 Viewers are encouraged to draw
00:13 their own conclusions about the information presented.
00:38 Hello, I'm Dr. Emerson, I'm Medical Director
00:41 at Eden Valley Lifestyle Center. I wanted to share
00:43 with you today some concepts about diabetes.
00:47 Our's is continuing on the talk we've done previously.
00:51 And in that talk we discovered that diabetes state can actually
00:56 be brought on fairly quickly with oils and animal fats.
01:04 Dr. Sweeney did this in 1927 with six medical students.
01:07 They were able to induce the diabetic state
01:09 in about two days. He was unable to do the same
01:12 thing with high sugar, or a high starch diet.
01:16 We found that this has been confirmed in human studies
01:20 and animals studies since then.
01:23 At this time we'd also like to look at some other aspects
01:26 that can effect insulin resistance and diabetes.
01:36 What we found initially was that when you take a sugar or starch,
01:41 its a review, your blood sugar would go up,
01:44 the pancreas would sense that, release insulin and insulin
01:47 would act as a little key, which would go into the cells
01:49 of each of the doors, open up the doors,
01:51 allow the sugar to leave the blood
01:53 and go in the cells and be burned.
01:55 This will bring your blood sugar down.
01:56 And that's the way it's suppose to work.
01:58 We found as the animals products, the fats,
02:01 the oils will tend to go in to the body when they're ingested
02:04 and then plug up those insulin receptors.
02:07 So that now when you take a sugar or starch,
02:09 blood sugar goes up, insulin is released,
02:11 can't get in the key holes, doors are shut
02:14 and the blood sugars rise, because they have nowhere to go.
02:16 And, that was essentially what we covered.
02:19 That's how insulin resistance can be induced
02:22 actually fairly quickly. There are some other factors
02:25 that we now know effect diabetes as well.
02:30 Among those are understanding of what fiber does for us,
02:35 fiber in the plant foods, also something called
02:38 the glycemic index of foods, in carbohydrates.
02:42 And also, something found in grains, that whole grains have,
02:46 which help protect us against diabetes,
02:48 but refined grains do not have. So, firstly what,
02:55 what does fiber do to protect us from diabetes.
03:00 Actually one of the things fiber does is it acts as a sponge.
03:04 It, when it's eaten with sugars or carbohydrates,
03:09 it hangs on the fluid and sugar, and that fiber helps release
03:14 the sugar into the blood stream from the gut slowly, overtime.
03:19 When fiber is not there,
03:21 we tend to get a rather severe jolt of sugar,
03:25 which is released in the blood stream fairly quickly.
03:28 This is illustrating some tests done with apple juice and apples
03:35 What they found is that if a person eats an apple,
03:38 which has the sugar with the fiber,
03:41 the sugar is in the gut and it's absorbed by the fiber
03:47 and it's released into the blood stream fairly slowly.
03:51 The sugar rises, the pancreas senses this,
03:54 releases a normal amount of insulin and this helps
03:58 slow the rise and helps prevent the blood sugar
04:00 from going too high. If it gets to stays below 150
04:04 and then it starts coming back down and as the sugar drops,
04:09 the insulin levels drop as well and the sugar plateaus
04:13 at about 100 or 90 or so and does not drop too low.
04:18 And this is the way it's supposed to work.
04:21 If on the other hand, we take that same apple,
04:24 the same calories, same 100 calories
04:26 and take it in the form of apple juice. We find is,
04:30 when that's entered into the gut, the sugar goes into
04:34 the blood stream very quickly. There is no fiber
04:36 to slow it down. The blood sugar starts to go up
04:39 fairly quickly, fairly dramatically.
04:41 The pancreas kind of overreacts, releases a lot of insulin
04:45 to prevent the blood sugar from going too high.
04:48 While the insulin load goes into the blood,
04:53 it starts, the sugar coming down again.
04:56 This time the sugar comes down, but as it approaches say normal
05:00 at a 100 or 90, there is no more sugar in the gut
05:06 coming into the blood stream, because its come in so quickly,
05:09 there is nothing left. So, the sugar supply to the blood
05:12 is cut off, but there is still a lot of insulin
05:14 in the blood and that drives the blood sugar too low.
05:18 This will make a person hypoglycemic maybe in hour
05:22 or two hours after the high sugaring meal.
05:25 And this is where they may get hypoglycemic,
05:28 have a hypoglycemic reaction, get shaky,
05:30 tremor-y and at that point they feel a need to
05:35 have a coffee break.
05:36 And, this is where the 10 O'clock coffee break comes in
05:38 people needing to get something to get their sugars up again.
05:43 They will take many times a caffeinated beverage,
05:46 which can stimulate blood sugar rise even without sugar
05:49 and then they have a sugary meal which sends
05:52 the blood sugar up again. This causes a blood sugar
05:57 drop again and the cycle is repeated.
06:01 And this is a cyclic problem then, that happens around noon
06:06 or 2 O'clock in the afternoon
06:10 after they have a sugary meal at lunch,
06:12 they get another spike and drop.
06:15 Then at 2 O'clock they need another sugar fix,
06:18 things go up, they come crashing down
06:21 around 5 O'clock, you have to have meal.
06:23 And the meal is another sugary meal,
06:26 it causes blood sugar to go up and around 7 O'clock
06:29 it comes crashing down. You've to have another snack
06:32 and then you go to sleep and hopefully you can make it
06:36 through the night without having another sugar dive.
06:39 I experienced this in college and it occurred to me in college
06:42 I said this is strange, you know,
06:43 I used to be able to go from breakfast to lunch
06:46 without having to have a 10 O'clock sugar fix.
06:50 And, when I went back to a high fiber diet,
06:55 plant-based diet without the sugary spikes,
06:59 I was able to go from breakfast to lunch without having
07:03 a hypoglycemic episode or needing the coffee breaks.
07:10 Another factor in foods that can help
07:14 even out your blood sugars, especially
07:16 if you are diabetic is a concept of a glycemic index.
07:20 Glycemic index is how fast sugar goes from your gut
07:25 into your bloodstream and if this happens slowly,
07:30 you have a low glycemic index food.
07:33 If you have a high glycemic index food,
07:35 the same 100 calories will go into your bloodstream
07:37 very quickly and cause a sugar spike and you're at risk
07:41 for that hypoglycemic episode again.
07:44 High glycemic index foods, sugar, table sugar has about
07:49 the same high glycemic index as refined white flour.
07:56 Potatoes, white potatoes have a high glycemic index.
08:00 The low glycemic index foods which are the best especially
08:03 for people coming off of the diabetic state would be the
08:07 lentils, beans, peas, these are the legume families.
08:12 They release their sugar into the bloodstream
08:14 very slowly over a long period of time.
08:17 Even sweet potatoes have a low glycemic index.
08:19 And, you can actually go to nutrition books
08:21 and get tables of food with different glycemic indexes.
08:25 They have shown that... we've experienced that
08:28 if you want to even out your blood sugars.
08:31 If you have large bowl of beans or lentils for breakfast,
08:36 one or two bowls, you will find that you are able to last
08:40 from breakfast o usually about 2 O'clock in the afternoon,
08:42 without getting hungry or having those crashes.
08:47 It's very effective for diabetics and helping them
08:51 control the blood sugars. Another aspect of foods
08:56 that can help prevent diabetes are the whole grains.
09:00 They have found that whole grains can decrease
09:03 insulin resistance. They also reduce your risk
09:07 of diabetes and your risk of heart disease.
09:10 And this is independent of the fiber that's in the whole grains
09:15 So, we believe that it has something to do with
09:17 the phytochemicals that are in whole grains which are
09:20 removed when you take out the bran and the germ.
09:27 In processing foods, the grains, the bran,
09:35 the outside covering of the grain, as well as the germ
09:38 are many times removed and those have over 90 percent
09:42 of the phytochemicals. And these chemicals
09:44 are chemicals your body uses to help
09:49 prevent diabetes and also help prevent cancers.
09:52 This strengthens your immune system,
09:54 you can't get these phytochemicals
09:55 from animal products, they have to be obtained in your foods.
09:58 And, whole grains are one of the best sources of these,
10:01 and we believe that's one of the reasons why
10:03 whole grains can prevent diabetes.
10:08 We want to talk another, about another concept in diabetes now.
10:13 If you recall, Dr. Anderson was able to get diabetics
10:18 who were on their pills, about 90 percent
10:20 of them off their pills on a plant-based diet.
10:22 If they were taking insulin, he was able to get about
10:25 75 percent of the patients on insulin off their medications.
10:30 The question is, why wasn't it a 100 percent?
10:34 Was there something else going on which was
10:37 preventing that small percentage from being
10:40 able to be come off their pills and the answer is yes.
10:44 There is something that we now understand
10:45 is called beta cell burnout. Beta cell burnout is
10:54 when the beta cells in the pancreas
10:57 which produce the insulin start burning out.
11:00 They stop being able to produce and release insulin.
11:08 They've found that unless you have beta cell burnout,
11:11 the insulin resistance will not progress to diabetes.
11:17 In other words, in order to get diabetes,
11:19 you've got to have insulin resistance,
11:21 plus this beta cells burnout. Now we are again,
11:24 we are talking about Type 2 diabetes.
11:27 They did some baboon studies to illustrate this.
11:32 They took some normal healthy baboons,
11:34 they gave them nicotinic acid, which causes marked insulin
11:39 resistance in the doses that they gave them to these baboons.
11:42 But, the baboons responded by just increasing the amount of
11:46 insulin they released and they overcame this insulin resistance
11:49 And, this allowed them to prevent their blood sugars
11:53 from going too high. Next, they took some baboons
11:59 and this time they destroyed half of the pancreas
12:04 with a special poison. Now their pancreas was only half there.
12:09 Now when they gave them the nicotinic acid
12:11 the insulin resistance rose,
12:13 the pancreas tried to compensate by releasing more insulin,
12:17 but was unable to do so, because half of it was missing
12:20 and they went on to develop diabetes.
12:24 So they needed the both components to develop diabetes,
12:28 insulin resistance plus beta cell burnout.
12:32 They have also observed that in humans there is a particular
12:37 rare genetic dysfunction which causes
12:43 a severe insulin resistance. But, many times these patients
12:46 do not develop diabetes because their pancreas
12:50 is able to just produce more insulin and compensate for it,
12:55 so the blood sugars can stay in the normal range.
13:00 What they have found with beta cell burnout is that it occurs,
13:05 or starts to occur 12 years before the diagnosis of diabetes
13:10 And, this is also where you can find
13:13 insulin resistance starting to increase.
13:16 What they are finding is that for about 12 years
13:18 before the diagnosis of diabetes,
13:23 until after about 12 years they are then diagnosed with diabetes
13:28 What happens as the insulin resistance increases initially
13:31 is the pancreas just releases more insulin
13:33 to compensate for it. So insulin levels actually go up,
13:37 up, until the time of diagnosis,
13:41 say at 12 years after the start of this process.
13:45 During that time of increasing insulin
13:47 resistance beta cell function is continuing to drop.
13:52 Now beta cell function, God has produced us with a big reserve,
13:58 so that they may, a normal person maybe able to produce
14:01 maybe say 10 times as much insulin
14:04 as they would really need. But by the time of diagnosis
14:08 of diabetes, that beta cell function is 50 percent,
14:12 it may only be able to produce maybe five times as much insulin
14:14 or somewhere in that neighborhood.
14:18 And at this time, the insulin resistance
14:20 however has increased to a point where it may need
14:22 that much more insulin to keep the blood sugars controlled.
14:27 So after 12 years the pancreas can no longer keep up with the
14:31 insulin resistance and now the blood sugar starts to rise.
14:36 And, now the doctors say oh, your blood sugars are rising
14:40 and you get diagnosed with diabetes.
14:47 What causes beta cell burnout? Well there are many theories,
14:54 some thoughts were that well high blood sugars
14:56 would be toxic to the pancreatic cells
14:59 or there are some glycosylation of pro teins or sugars
15:02 were combined with the proteins in the pancreas
15:03 and that would cause damage or amyloid deposition.
15:07 But all of these processes required high blood sugars.
15:10 And, as we noted, this beta cell burnout
15:13 occurs 12 years before the diagnosis of diabetes
15:17 when the blood sugars are normal.
15:19 So, they had to understand or find a different mechanism
15:23 and they found that the mechanism was most likely
15:25 is what they call lipotoxicity.
15:28 When you have insulin resistance, two things happen,
15:32 your triglycerides go up,
15:35 that's the fat in the blood and insulin levels rise.
15:39 Now insulin not only drives sugar into cells to be burned
15:46 or stored. It not only drives
15:48 sugar into those cells to be stored,
15:50 but insulin will also drive fat into fat cells to be stored.
15:54 It will drive fat into liver cells causing fatty liver,
15:58 but it can also cause dry fat into pancreatic cells
16:02 which can cause beta cell burnout.
16:05 It could be toxic to those pancreatic cells.
16:10 What we found also is that this has been
16:14 confirmed with the Pima Indians and Caucasians.
16:18 What they found is that if they give a high fat diet
16:23 to these groups of people, very soon,
16:27 the beta cell function starts decreasing.
16:32 And it's related to the fat in the diet,
16:34 the insulin resistance and the high triglycerides
16:38 and the increase in insulin that is being produced,
16:41 causing that lipotoxicity in the pancreas.
16:45 Well, many patients want to know,
16:49 how do I know if my pancreas is working,
16:52 or how well it's working?
16:56 If their pancreas is working well,
16:59 if they are producing enough insulin,
17:03 then if we just get rid of the insulin resistance,
17:06 we would expect to be able to get them off the medications.
17:08 However, if their pancreas is working at a very low level,
17:13 where they are not producing much insulin at all,
17:16 even though you get rid of the insulin resistance,
17:18 you still have a second problem where you're not producing
17:22 enough insulin and they still need insulin to maintain
17:26 their blood sugars. So, how do I know, how do I know?
17:30 Well, there is a test called C-terminal peptide,
17:32 which you can ask your doctor about.
17:34 You can obtain, it's just a simple blood test.
17:38 What happens is insulin is, starts as proinsulin
17:45 and it's protein and to turn it into insulin,
17:49 one of the ends is broken off, that's called the
17:51 C- terminal peptide end, it's broken off
17:55 and kind of thrown away into the blood
17:56 and what's left is your insulin, the insulin goes out
17:59 and does the work it's suppose to do.
18:01 But, the C-terminal peptide floats around the blood stream
18:04 and its level can let you know how much you're producing.
18:09 Now, if I inject insulin there is no
18:13 C- terminal peptide in the insulin I'm injecting.
18:16 So, even if a patient is taking insulin,
18:19 we can measure their C- peptide and it will tell us
18:22 how much insulin that person is making,
18:25 even apart from the insulin they are getting injected.
18:30 So, what's normally done is we give a sugary meal
18:34 or something to drive the sugar up above 150.
18:37 This will stimulate the pancreas to release
18:40 as much insulin as it can.
18:43 And then once the blood sugar is above 150
18:46 we draw a blood test and we measure the C-peptide level.
18:50 If a C-peptide level is four or above,
18:53 that generally indicates fairly good pancreatic function
18:58 and you would have a very good chance of getting
19:00 off your medicines, if you were to change your diet
19:04 and get rid of the insulin resistance.
19:06 If on the other hand it's two or less, chances are not as good,
19:10 chances are less likely that you are going to be able to get off
19:13 your medications even if you get rid of the insulin resistance,
19:18 because you're still going to need to produce
19:20 more insulin and that may take sometime to correct.
19:25 Well the next question that would
19:27 follow is beta cell burnout reversible?
19:32 And the good news is there is evidence that yes it is.
19:36 There are some drugs, TCD's they are called.
19:41 They're a class of drug which helps decrease
19:45 insulin resistance, as well as decrease triglyceride levels.
19:51 And, these two factors tend to increase
19:55 the function of the beta cell
19:57 if the medicines are started soon enough.
20:02 They can increase and some tests have shown
20:05 as much as 60% increase in beta cell function
20:07 in as little as 6 months.
20:12 The problem with these is that they are some side effects
20:14 and they will cause usually 5 to 10 pound
20:17 weight gain during that time period.
20:19 Something most diabetics would like to avoid.
20:23 On the other hand, if you move to a plant based diet,
20:27 you can also drop your triglycerides,
20:30 decrease insulin resistance and beta cell function can increase.
20:35 It may take 3, 6 months, 12 months,
20:38 it may take sometime for that beta cell function to increase.
20:41 But if a person persist on it,
20:45 this is something that they can hope for
20:47 and actually measure and follow
20:50 and see if the pancreas is indeed getting better.
20:53 The nice thing about a plant based diet
20:55 is it doesn't cause the weight gain that the TCD's will cause.
21:00 In fact it can cause in general a weight loss,
21:04 and that's something that again most
21:06 diabetics are looking forward to.
21:10 Well, at the beginning of our first talk on diabetics
21:14 we described a lady who came into our office
21:17 and I wanted to tell you the rest of the story.
21:19 If you remember her name is Tony,
21:21 and she came into the office she rolled in,
21:23 in a wheel chair. 5Ft 3, she is actually
21:26 325 pounds she was blind from a diabetics
21:30 she was on 44 units of insulin a day.
21:34 She had high blood pressure, she had high cholesterol.
21:38 And, as you now know
21:39 this is all part of the insulin resistance syndrome.
21:42 Its part of the insulin resistance that she has
21:46 and it was causing all of these problems.
21:48 She had... the blindness was from a diabetic retinopathy
21:52 a common side effect of diabetes.
21:56 Well, I shared with her basically the things
22:00 that I shared with you and she did something
22:06 very strange, very unusual,
22:08 something we weren't really excepting,
22:10 she actually did everything we asked her to do.
22:15 She was in a wheel chair, she wasn't able to exercise
22:19 or get around much at all, but she moved to plant based diet.
22:25 No calorie restriction in a wheel chair,
22:27 no real exercise. But within about 2 months,
22:33 her blood pressure started coming down.
22:38 And as the blood pressure comes down,
22:40 we had to start taking her off her blood pressure medicines
22:43 or it would go too low. In about 2 months,
22:46 she was off of her blood pressure medicines
22:50 not needing that anymore.
22:51 She continued on her program
22:53 and we had to start decreasing her insulin level,
22:57 her insulin doses because her blood sugars
23:00 were starting to go too low.
23:03 Her blood sugars started coming down
23:06 and also we followed her cholesterol levels,
23:10 her cholesterol levels started coming down.
23:13 At the end of one year, her cholesterol had dropped
23:20 so low that we had to take her off
23:21 of her cholesterol medicines.
23:24 And at the end of a year she was off of her insulin.
23:27 She's gotten off of her insulin.
23:29 She was just on some oral medications at that time.
23:32 The other amazing thing we found was that
23:34 her weight started dropping.
23:37 She went from 325 down to 211 in 2 years.
23:44 That was approximately a pound a week
23:47 with no calorie restriction, no exercise,
23:50 she was in a wheel chair
23:52 and just by changing to a plant-based diet.
23:58 She was then able to get a knee surgery
24:01 from orthopedic surgeon and she started walking again.
24:06 And as long as she stayed on the program,
24:09 blood sugar stayed good, blood pressure stayed good,
24:11 cholesterol stayed good. If she strayed off the program,
24:15 started having animal products again.
24:18 Blood sugars will start to rise, cholesterol rise,
24:21 blood pressure would rise, weight would rise.
24:22 She had to come back on track to even it out again.
24:26 And, she did very well as long as
24:28 she stayed on the program.
24:31 So, the take home message is that,
24:35 what we found is that on a animal based diet,
24:40 American diet, lot of fats will go in
24:42 and plug up those insulin receptors.
24:44 So that when you take a sugar starch
24:46 blood sugar goes up, insulin is released
24:48 can't get in the key holes,
24:49 doors are stuck and the blood sugars rise,
24:52 that's insulin resistance. When this happens
24:55 the pancreas compensates by releasing more insulin.
24:59 That insulin tends to drive fat into fat cells,
25:04 making people heavy, drives fat into liver cells
25:08 causing fatty liver, drives fat into pancreatic cells
25:12 causing beta cell burn out.
25:15 And with time the beta cells will start to burn out,
25:19 you have decreased production of insulin
25:23 and with time then you'll have both beta cell miss function,
25:28 not enough insulin being able to be produced
25:30 to compensate for the insulin resistance
25:32 that the American diet has.
25:35 If you choose like Tony did, to go on a plant based diet
25:40 this can reverse.
25:41 Insulin resistance generally reverses within 3 or 4 days,
25:45 sometimes a week or two, usually 3 or 4 days.
25:49 Beta cell function on the other hand
25:51 may take 3, 6 months or longer before
25:56 it can recover and recoup.
25:59 So, for patients who are on diabetic medications,
26:04 wanting to make a change,
26:07 we encourage you to work with your doctor,
26:09 say, you know I'm gonna try a lifestyle change.
26:12 I want to be letting you know, what my blood sugars are
26:14 as the blood sugars come down
26:16 stay in touch with your doctor, so he can adjust your insulin,
26:19 so that your blood sugars don't go too low.
26:22 You want to keep in touch with him,
26:25 so that you can make those adjustments as needed.
26:29 And, as you make these changes what should occur,
26:34 what you should be watching for,
26:35 is blood sugar should be dropping,
26:37 blood pressure should be dropping.
26:39 You would need to keep your doctor apprised to those,
26:41 so that if needed he can adjust your blood pressures down.
26:45 Weight should be dropping,
26:47 cholesterol levels should be dropping,
26:49 and again it would be good
26:50 to keep a check on your cholesterol,
26:52 because if you're on cholesterol medicines
26:53 you do have a good chance
26:55 of being able to get off your cholesterol medicines.
26:58 So you want to keep in touch with him, keep him appraised,
27:01 so that you're not over medicating yourself.
27:05 These are things that God has given us,
27:11 the plant-based foods, which can strengthen the body.
27:14 In many cases, reverse and heel
27:16 the body even after many damage has been done.
27:19 As we move back to the original diet
27:23 that was given to us in the Garden of Eden.
27:25 We find that many diseases and illnesses
27:28 can in fact reverse and improve.
27:31 So, I encourage you to take a challenge,
27:36 try some of these lifestyle changes
27:39 and I wish you God's blessing and His health,
27:45 for He does desire you to be in good health.
27:49 We thank you for listening
27:50 and we hope that you can experience the health
27:58 and strength that God desires you to have.
28:01 Again, thank you for listening.
28:04 We hope you'll tune in again next time for more talks.


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Revised 2014-12-17